Not known Factual Statements About rheumatoid arthritis test

Many people around the globe suffer from an immune system that doesn't discern between healthy cells, invading bacteria, or diseases. The defenses against diseases that were once protecting themselves are now attacking their organs and tissues.




International research is underway to combat the growing trend. This includes a project at London's Francis Crick Institute where two world experts, James Lee, and Carola Vinuesa have created separate research groups to identify the causes of autoimmune diseases.


Lee revealed to the Observer how the number of autoimmune cases has increased over the last 40 years in the West. But, some of these cases are now occurring in countries where they have never suffered from the disease.


For instance the Middle East/east Asia is the region that has seen the highest recent rise in the number of inflammatory bowel disease cases. The patients had never previously had the disease before.


Type 1 diabetes, multiple sclerosis, inflammatory bowel disease and rheumatoidarthitis are all autoimmune diseases. In all instances the immune system is activated and it starts to attack healthy tissues.


There are at least 4,000,000 people with autoimmune conditions in the UK as well as some suffering from more than one. In the world, it is believed that the number of cases of autoimmune diseases is rising by anywhere between 3 and 9 percent per year. Most scientists believe environmental factors play a major part in this increase.


Lee who was based in Cambridge University, stated that genetics has not changed over recent decades. There's got to be something external that's causing our predisposition for autoimmune disease.


Vinuesa agreed with the idea she was a former employee at the Australian National University. She mentioned the shifts in food habits that took place as more countries adopted west-style diets, and people consumed more fast foods.


Vinuesa stated that the lack of essential ingredients in fast-food food can result in a decrease in the intake of essential nutrients, including fibre.


These changes in the microbiomes can then trigger autoimmune diseases. More than 100 different types of autoimmune diseases have been discovered.


The two scientists agreed that people are susceptible to getting these diseases. These include celiac and lupus, which can trigger swelling and inflammation and lead to damage to various organs including the heart.


Vinuesa explained that autoimmune diseases aren't something you could be diagnosed with if you don't have a specific genetic susceptibility. It's impossible to stop the expansion of fast-food establishments all over the world. Instead, we're working to understand how autoimmune diseases can be caused and what genetic causes can make some people more susceptible to the disease than others. That's the level where we plan to address this issue."


This is made possible due to the advancement of methods that allow researchers to identify tiny differences in DNA between large numbers of people. This allows them to recognize common genetic patterns that are common to individuals suffering from an autoimmune disease.


In the past we didn't have the tools to do this, but we're in a position to sequence DNA on a huge scale, and it has transformed everything, said Lee. When I started doing studies, we were aware of fifty DNA variants that were involved in triggering an inflammatory bowel disease. Now, we know about 250.


Lee and Vinuesa have been pursuing such work because they want to know how the genetic pathways work and what causes the different illnesses that doctors are currently studying. Vinuesa has stated that there are a variety of variations of autoimmune diseases, such as Lupus. This could have an adverse impact on your ability to determine the best treatment.


There are many promising treatments that may be beneficial however, we do not have the appropriate patients. In fact, we don’t have the necessary information to know if these patients suffer from the same disease. This is an important aspect in the field of autoimmune research. It is essential to learn how to stratify and group patients to provide them the right therapy.


Lee explained that, with the increase in autoimmune diseases across the world, new therapies and medicines are required more urgently than ever. There are currently no treatments for autoimmune disease that are most often seen in young peoplewho are trying to land their first job, graduate from school, and raise their families.


This means that more and more of people will have to undergo surgery or have regular injections. It's a bleak time for patients, and put a huge pressure on health services. It is urgent to discover new, more effective treatments.


Rheumatoid Arthritis is an autoimmune disorder. This means that the immune system attacks healthy tissue. It's unclear what causes this.


Your immune system normally produces antibodies that fight bacteria and viruses in order to fight off infection.


If you have rheumatoid the immune system issuing antibodies towards the joint's lining, where they attack adjacent tissue.


The delicate layer of cells (synovium) that covers your joints, is prone to inflammation and swollen.


bones

Cartilage is the connective tissue between bones which is composed of cartilage.

Tendons - the tissues that connects muscle and bone

Ligaments - The connective tissue between cartilage and bone

If rheumatoid joint disease isn't treated, Read More these chemicals gradually cause the joint to loose its form and align. The final result may be irreparable.


There are many theories about why the immune system attacks joints have been proposed for example, an infection as the trigger, but none of them has been proved.

Possible risk factors

There are a variety of factors that may increase your risk of developing rheumatoid arthritis such as:


You can inherit it from your genes. While there are indicators that suggest that rheumatoidarthritis could be passed down the generations but the odds of developing it are low because genes play a tiny Read More role in the disease.

Hormones-Rheumatoid Ailment is more common among women than males. It could be due to the estrogenic effects, but this has not been proved.

smoking - some evidence suggests that smokers are at a higher risk of developing rheumatoid joint